{"id":3070,"date":"2023-05-18T08:33:50","date_gmt":"2023-05-18T08:33:50","guid":{"rendered":"https:\/\/iscpif.fr\/chavalarias\/?p=3070"},"modified":"2024-02-06T23:48:36","modified_gmt":"2024-02-06T23:48:36","slug":"exploring-browsing-and-interacting-with-multi-level-and-multi-scale-dynamics-of-knowledge-2-2","status":"publish","type":"post","link":"https:\/\/iscpif.fr\/chavalarias\/?p=3070","title":{"rendered":"JCE: Toward an observatory of the evolution of clinical trials through phylomemy reconstruction"},"content":{"rendered":"<div id='full_slider_1'  class='avia-fullwidth-slider main_color avia-shadow   avia-builder-el-0  el_before_av_one_half  avia-builder-el-first   container_wrap fullsize'  ><div  class='avia-slideshow av-kty8ss3t-ffbc54175a0054500175e0eb2512a65d avia-slideshow-featured av_slideshow_full avia-slide-slider av-slideshow-ui av-control-default av-slideshow-manual av-loop-once av-loop-manual-endless av-default-height-applied   avia-slideshow-1' data-slideshow-options=\"{&quot;animation&quot;:&quot;slide&quot;,&quot;autoplay&quot;:false,&quot;loop_autoplay&quot;:&quot;once&quot;,&quot;interval&quot;:5,&quot;loop_manual&quot;:&quot;manual-endless&quot;,&quot;autoplay_stopper&quot;:false,&quot;noNavigation&quot;:false,&quot;bg_slider&quot;:false,&quot;keep_padding&quot;:false,&quot;hoverpause&quot;:false,&quot;show_slide_delay&quot;:0}\"  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><ul class='avia-slideshow-inner ' style='padding-bottom: 28.666666666667%;'><li  class='avia-slideshow-slide av-kty8ss3t-ffbc54175a0054500175e0eb2512a65d__0  av-single-slide slide-1 slide-odd'><div data-rel='slideshow-1' class='avia-slide-wrap '   ><div class='av-slideshow-caption av-kty8ss3t-ffbc54175a0054500175e0eb2512a65d__0 caption_fullwidth caption_left caption_left_framed caption_framed'><div class=\"container caption_container\"><div class=\"slideshow_caption\"><div class=\"slideshow_inner_caption\"><div class=\"slideshow_align_caption\"><h2 class='avia-caption-title '  itemprop=\"name\" >Journal of Clinical Epidemiology<\/h2><div class='avia-caption-content '  itemprop=\"description\" ><p>Toward an observatory of the evolution of clinical trials through phylomemy reconstruction: the COVID-19 vaccines example<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><img decoding=\"async\" fetchpriority=\"high\" class=\"wp-image-3073 avia-img-lazy-loading-not-3073\"  src=\"https:\/\/iscpif.fr\/chavalarias\/wp-content\/uploads\/sites\/4\/2023\/05\/phylomemy-randomized-unrandomized--1500x430.png\" width=\"1500\" height=\"430\" title='phylomemy-randomized-unrandomized-' alt=''  itemprop=\"thumbnailUrl\"   \/><\/div><\/li><\/ul><\/div><\/div><div id='after_full_slider_1'  class='main_color av_default_container_wrap container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-3070'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-4k5gxk-b4b3ea55fc842455c5a569c43fce10e2\">\n.flex_column.av-4k5gxk-b4b3ea55fc842455c5a569c43fce10e2{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-4k5gxk-b4b3ea55fc842455c5a569c43fce10e2 av_one_half  avia-builder-el-1  el_after_av_slideshow_full  el_before_av_one_half  avia-builder-el-first  first flex_column_div av-zero-column-padding  '     ><p><section  class='av_textblock_section av-kweq3nln-b9f868af87bafbcfacd18c7352555c0b '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Reference: <\/strong>Lobb\u00e9, Q., Chavalarias, D., Delano\u00eb, A., Ferrand, G., Cohen-Boulakia, S., Ravaud, P., Boutron, I., 2022. Toward an observatory of the evolution of clinical trials through phylomemy reconstruction: the COVID-19 vaccines example. Journal of Clinical Epidemiology. <a href=\"https:\/\/doi.org\/10.1016\/j.jclinepi.2022.05.004\">https:\/\/doi.org\/10.1016\/j.jclinepi.2022.05.004<\/a><\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-kty8t81k-3213f0785fe36118b5795bc8dd48d668\">\n#top .av-special-heading.av-kty8t81k-3213f0785fe36118b5795bc8dd48d668{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-kty8t81k-3213f0785fe36118b5795bc8dd48d668 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-kty8t81k-3213f0785fe36118b5795bc8dd48d668 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-kty8t81k-3213f0785fe36118b5795bc8dd48d668 av-special-heading-h4  avia-builder-el-3  el_after_av_textblock  el_before_av_textblock '><h4 class='av-special-heading-tag '  itemprop=\"headline\"  >Abstract<\/h4><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-kty8tkyz-96b5999e90662e7f992350f0e326071f '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Objective. <\/strong>To visualize the evolution of all registered COVID-19 vaccines trials<\/p>\n<p><strong>Study Design and Setting.<\/strong> As part of the living mapping of the COVID-NMA initiative, we identify biweekly all COVID-19 vaccine trials and automatically extract data from the EU clinical trials registry, ClinicalTrials.gov, IRCT and the WHO International Clinical Trials Registry Platform. Data are curated and enriched by epidemiologists.<br \/>\nWe have used the phylomemy reconstruction process to visualize the temporal evolution of COVID-19 vaccines trials descriptions. We have analyzed the textual contents of 1,794 trials descriptions (last search in October 2021) and explored their collective structure along with their semantic dynamics.<\/p>\n<p><strong>Results.<\/strong> The structures highlighted by the phylomemy reconstruction processes synthesize the complexity of the knowledge produced by the research community. The reconstructed phylomemy clearly retrieves the five major COVID-19 vaccine platforms in the form of complete branches. The branches interactions reflect the exploration of a new approach to vaccine implementation moving from homologous prime vaccination to heterologous prime vaccination. Phylomemies also clearly identifies shifts in research questions; from vaccine efficacy to booster efficacy.<\/p>\n<p><strong>Conclusion. <\/strong>this new method provides important insights for the global coordination between research teams especially in crisis situations such as the COVID-19 pandemic.<\/p>\n<\/div><\/section><\/p><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2k2iq0-48265c54f0627b87d015936dcaf02755\">\n.flex_column.av-2k2iq0-48265c54f0627b87d015936dcaf02755{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-2k2iq0-48265c54f0627b87d015936dcaf02755 av_one_half  avia-builder-el-5  el_after_av_one_half  el_before_av_one_full  flex_column_div av-zero-column-padding  '     ><div  class='avia-icon-list-container av-kty8vo28-eb2323a6a326819290866fc7245a409e  avia-builder-el-6  avia-builder-el-no-sibling '><ul class='avia-icon-list avia_animate_when_almost_visible avia-icon-list-left av-iconlist-big av-kty8vo28-eb2323a6a326819290866fc7245a409e avia-iconlist-animate'>\n<li><div class='iconlist_icon av-kty8u3hl-4b8302a0af8925fbe2244f93a431f029 avia-font-entypo-fontello avia-iconfont avia-font-entypo-fontello'><span class='av-icon-char' data-av_icon='\ue80b' data-av_iconfont='entypo-fontello' aria-hidden=\"true\"><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class=\"iconlist_content_wrap\"><header class=\"entry-content-header\" aria-label=\"Icon: Authors\"><h4 class='av_iconlist_title iconlist_title  '  itemprop=\"headline\" >Authors<\/h4><\/header><div class='iconlist_content '  itemprop=\"text\" ><div class=\"csl-bib-body\">\n<div class=\"csl-entry\">Lobb\u00e9, Q., Chavalarias, D., Delano\u00eb, A., Ferrand, G., Cohen-Boulakia, S., Ravaud, P., Boutron,<\/div>\n<\/div>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class=\"iconlist-timeline\"><\/div><\/li>\n<li><div class='iconlist_icon av-kty8unq9-0c2e85dee15f07d951dd3af84e851e32 avia-font-entypo-fontello avia-iconfont avia-font-entypo-fontello'><span class='av-icon-char' data-av_icon='\ue84d' data-av_iconfont='entypo-fontello' aria-hidden=\"true\"><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class=\"iconlist_content_wrap\"><header class=\"entry-content-header\" aria-label=\"Icon: Pre-print of the paper\"><h4 class='av_iconlist_title iconlist_title  '  itemprop=\"headline\" >Pre-print of the paper<\/h4><\/header><div class='iconlist_content '  itemprop=\"text\" ><p>See the<a href=\"https:\/\/hal.science\/hal-03500847\" target=\"_blank\" rel=\"noopener\"> pre-print of the paper<\/a><\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class=\"iconlist-timeline\"><\/div><\/li>\n<li><a href='https:\/\/journals.sagepub.com\/doi\/full\/10.1177\/14738716211044829' title='View on Publisher\u2019s website'  target=\"_blank\"  rel=\"noopener noreferrer\" class='iconlist_icon av-kty8vhr3-59c9a21752d277446345085b05b207f4 avia-font-entypo-fontello avia-iconfont avia-font-entypo-fontello'><span class='av-icon-char' data-av_icon='\ue835' data-av_iconfont='entypo-fontello' aria-hidden=\"true\"><\/span><\/a><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class=\"iconlist_content_wrap\"><header class=\"entry-content-header\" aria-label=\"Icon: &lt;a href=&#039;https:\/\/journals.sagepub.com\/doi\/full\/10.1177\/14738716211044829&#039; title=&#039;View on Publisher\u2019s website&#039; target=&quot;_blank&quot;  rel=&quot;noopener noreferrer&quot;&gt;View on Publisher\u2019s website&lt;\/a&gt;\"><h4 class='av_iconlist_title iconlist_title  '  itemprop=\"headline\" ><a href='https:\/\/journals.sagepub.com\/doi\/full\/10.1177\/14738716211044829' title='View on Publisher\u2019s website' target=\"_blank\"  rel=\"noopener noreferrer\">View on Publisher\u2019s website<\/a><\/h4><\/header><div class='iconlist_content '  itemprop=\"text\" ><ul>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0895435622001263\">Full paper with SI<\/a> on Springer (restricted access)<\/li>\n<\/ul>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class=\"iconlist-timeline\"><\/div><\/li>\n<li><div class='iconlist_icon av-kweqw4jf-32667ebc38876964c1f2cb016d49ffc7 avia-font-entypo-fontello avia-iconfont avia-font-entypo-fontello'><span class='av-icon-char' data-av_icon='\ue843' data-av_iconfont='entypo-fontello' aria-hidden=\"true\"><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class=\"iconlist_content_wrap\"><header class=\"entry-content-header\" aria-label=\"Icon: Interactive phylomemies\"><h4 class='av_iconlist_title iconlist_title  '  itemprop=\"headline\" >Interactive phylomemies<\/h4><\/header><div class='iconlist_content '  itemprop=\"text\" ><ul>\n<li><a href=\"http:\/\/maps.gargantext.org\/phylo\/vaccines_fundings_10_2021\/\" target=\"_blank\" rel=\"noopener\">Phylolemy with founding organization highlitht<\/a><\/li>\n<li><a href=\"http:\/\/maps.gargantext.org\/phylo\/vaccines_countries_10_2021\/\" target=\"_blank\" rel=\"noopener\">Phylomemy with countries highlight<\/a><\/li>\n<li><a href=\"http:\/\/maps.gargantext.org\/phylo\/vaccines_phases_10_2021\/\" target=\"_blank\" rel=\"noopener\">Phylomemy with phases highlight<\/a><\/li>\n<li><a href=\"http:\/\/maps.gargantext.org\/phylo\/vaccines_publications_10_2021\/\" target=\"_blank\" rel=\"noopener\">Phylomemy with publication status (Yes\/No)<\/a><\/li>\n<li><a href=\"http:\/\/maps.gargantext.org\/phylo\/vaccines_publics_10_2021\/\" target=\"_blank\" rel=\"noopener\">Phylomemy with public tested<\/a> (immunodepressed, newborn, pregnant, etc.)<\/li>\n<\/ul>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class=\"iconlist-timeline\"><\/div><\/li>\n<\/ul><\/div><\/div><\/p>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-373zvi-7ab1dec2d69d85823aedeaf1840a76ba\">\n.flex_column.av-373zvi-7ab1dec2d69d85823aedeaf1840a76ba{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-373zvi-7ab1dec2d69d85823aedeaf1840a76ba av_one_full  avia-builder-el-7  el_after_av_one_half  avia-builder-el-last  first flex_column_div av-zero-column-padding  column-top-margin'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lhsvmcgb-d4a75674ad6ba0a9824604e4b476b3be\">\n#top .av-special-heading.av-lhsvmcgb-d4a75674ad6ba0a9824604e4b476b3be{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-lhsvmcgb-d4a75674ad6ba0a9824604e4b476b3be .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-lhsvmcgb-d4a75674ad6ba0a9824604e4b476b3be .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-lhsvmcgb-d4a75674ad6ba0a9824604e4b476b3be av-special-heading-h3  avia-builder-el-8  el_before_av_image  avia-builder-el-first '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >Randomized\/unrandomized Clinical trials<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lhsvmpgj-43870d4dd70906402e757f7c3a3ebb36\">\n.avia-image-container.av-lhsvmpgj-43870d4dd70906402e757f7c3a3ebb36 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-lhsvmpgj-43870d4dd70906402e757f7c3a3ebb36 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  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\/><\/div><\/div><\/div><\/p><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"featured_media":3074,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17,3],"tags":[],"class_list":["post-3070","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","category-toread"],"_links":{"self":[{"href":"https:\/\/iscpif.fr\/chavalarias\/index.php?rest_route=\/wp\/v2\/posts\/3070","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/iscpif.fr\/chavalarias\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/iscpif.fr\/chavalarias\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/iscpif.fr\/chavalarias\/index.php?rest_route=\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/iscpif.fr\/chavalarias\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3070"}],"version-history":[{"count":7,"href":"https:\/\/iscpif.fr\/chavalarias\/index.php?rest_route=\/wp\/v2\/posts\/3070\/revisions"}],"predecessor-version":[{"id":3321,"href":"https:\/\/iscpif.fr\/chavalarias\/index.php?rest_route=\/wp\/v2\/posts\/3070\/revisions\/3321"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/iscpif.fr\/chavalarias\/index.php?rest_route=\/wp\/v2\/media\/3074"}],"wp:attachment":[{"href":"https:\/\/iscpif.fr\/chavalarias\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3070"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/iscpif.fr\/chavalarias\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3070"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/iscpif.fr\/chavalarias\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3070"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}