“Facing metastasis is the most pressing challenge of cancer research. Our group has studied extensively phenotypic plasticity of cancer cells, highlighting the kinetics of cancer stem cell and the role of the epithelial mesenchymal transition for metastasis. To disentangle the complexity of environmentally induced phenotypic transitions, there is a growing need for novel advanced algorithms as those proposed in our recent work combining single cell data analysis and numerical simulations of gene regulatory networks. All together our results open interesting new applications to a personalized cancer treatment.”